Greasing the Path to BAX/BAK Activation
نویسندگان
چکیده
BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the threshold for apoptosis-associated cytochrome c release. Association of mitochondria with other cellular membrane compartments is required for BAK/BAX exposure to these sphingolipids.
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عنوان ژورنال:
- Cell
دوره 148 شماره
صفحات -
تاریخ انتشار 2012